Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.
Identifieur interne : 000F00 ( Main/Exploration ); précédent : 000E99; suivant : 000F01Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.
Auteurs : Nicole M. Davis [États-Unis] ; Melissa Sokolosky [États-Unis] ; Kristin Stadelman [États-Unis] ; Steve L. Abrams [États-Unis] ; Massimo Libra [Italie] ; Saverio Candido [Italie] ; Ferdinando Nicoletti [Italie] ; Jerry Polesel [Italie] ; Roberta Maestro [Italie] ; Antonino D'Assoro [États-Unis] ; Lyudmyla Drobot [Ukraine] ; Dariusz Rakus [Pologne] ; Agnieszka Gizak [Pologne] ; Piotr Laidler [Pologne] ; Joanna Duli Ska-Litewka [Pologne] ; Joerg Basecke [Allemagne] ; Sanja Mijatovic [Serbie] ; Danijela Maksimovic-Ivanic [Serbie] ; Giuseppe Montalto [Italie] ; Melchiorre Cervello [Italie] ; Timothy L. Fitzgerald [États-Unis] ; Zoya Demidenko [États-Unis] ; Alberto M. Martelli [Italie] ; Lucio Cocco [Italie] ; Linda S. Steelman [États-Unis] ; James A. Mccubrey [États-Unis]Source :
- Oncotarget [ 1949-2553 ] ; 2014.
Descripteurs français
- KwdFr :
- Complexe-1 cible mécanistique de la rapamycine (MeSH), Complexes multiprotéiques (génétique), Femelle (MeSH), Humains (MeSH), Phosphatidylinositol 3-kinases (génétique), Phosphatidylinositol 3-kinases de classe I (MeSH), Phosphohydrolase PTEN (génétique), Protéines proto-oncogènes c-akt (génétique), Récepteurs ErbB (génétique), Régulation de l'expression des gènes tumoraux (MeSH), Sérine-thréonine kinases TOR (génétique), Transduction du signal (génétique), Tumeurs du sein (génétique).
- MESH :
- génétique : Complexes multiprotéiques, Phosphatidylinositol 3-kinases, Phosphohydrolase PTEN, Protéines proto-oncogènes c-akt, Récepteurs ErbB, Sérine-thréonine kinases TOR, Transduction du signal, Tumeurs du sein.
- Complexe-1 cible mécanistique de la rapamycine, Femelle, Humains, Phosphatidylinositol 3-kinases de classe I, Régulation de l'expression des gènes tumoraux.
English descriptors
- KwdEn :
- Breast Neoplasms (genetics), Class I Phosphatidylinositol 3-Kinases (MeSH), ErbB Receptors (genetics), Female (MeSH), Gene Expression Regulation, Neoplastic (MeSH), Humans (MeSH), Mechanistic Target of Rapamycin Complex 1 (MeSH), Multiprotein Complexes (genetics), PTEN Phosphohydrolase (genetics), Phosphatidylinositol 3-Kinases (genetics), Proto-Oncogene Proteins c-akt (genetics), Signal Transduction (genetics), TOR Serine-Threonine Kinases (genetics).
- MESH :
- chemical , genetics : ErbB Receptors, Multiprotein Complexes, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases.
- chemical : Class I Phosphatidylinositol 3-Kinases, Mechanistic Target of Rapamycin Complex 1.
- genetics : Breast Neoplasms, Signal Transduction.
- Female, Gene Expression Regulation, Neoplastic, Humans.
Abstract
The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstream HER2 has been associated with breast cancer initiating cells (CICs) and in some cases resistance to treatment. The anti-diabetes drug metformin can suppress the growth of breast CICs and herceptin-resistant HER2+ cells. This review will discuss the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway primarily in breast cancer but will also include relevant examples from other cancer types. The targeting of this pathway will be discussed as well as clinical trials with novel small molecule inhibitors. The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be reviewed in association with suppression of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway.
DOI: 10.18632/oncotarget.2209
PubMed: 25051360
PubMed Central: PMC4148087
Affiliations:
- Allemagne, Italie, Pologne, Serbie, Ukraine, États-Unis
- Basse-Saxe, Caroline du Nord, Minnesota, Émilie-Romagne, État de New York
- Bologne, Göttingen
- Université de Bologne
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.</title><author><name sortKey="Davis, Nicole M" sort="Davis, Nicole M" uniqKey="Davis N" first="Nicole M" last="Davis">Nicole M. Davis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Sokolosky, Melissa" sort="Sokolosky, Melissa" uniqKey="Sokolosky M" first="Melissa" last="Sokolosky">Melissa Sokolosky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Stadelman, Kristin" sort="Stadelman, Kristin" uniqKey="Stadelman K" first="Kristin" last="Stadelman">Kristin Stadelman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Abrams, Steve L" sort="Abrams, Steve L" uniqKey="Abrams S" first="Steve L" last="Abrams">Steve L. Abrams</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Libra, Massimo" sort="Libra, Massimo" uniqKey="Libra M" first="Massimo" last="Libra">Massimo Libra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Bio-Medical Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Candido, Saverio" sort="Candido, Saverio" uniqKey="Candido S" first="Saverio" last="Candido">Saverio Candido</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Bio-Medical Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Nicoletti, Ferdinando" sort="Nicoletti, Ferdinando" uniqKey="Nicoletti F" first="Ferdinando" last="Nicoletti">Ferdinando Nicoletti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Bio-Medical Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Polesel, Jerry" sort="Polesel, Jerry" uniqKey="Polesel J" first="Jerry" last="Polesel">Jerry Polesel</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano</wicri:regionArea><wicri:noRegion>Aviano</wicri:noRegion></affiliation></author><author><name sortKey="Maestro, Roberta" sort="Maestro, Roberta" uniqKey="Maestro R" first="Roberta" last="Maestro">Roberta Maestro</name><affiliation wicri:level="1"><nlm:affiliation>Experimental Oncology 1, CRO IRCCS, National Cancer Institute, Aviano, Pordenone, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Experimental Oncology 1, CRO IRCCS, National Cancer Institute, Aviano, Pordenone</wicri:regionArea><wicri:noRegion>Pordenone</wicri:noRegion></affiliation></author><author><name sortKey="D Assoro, Antonino" sort="D Assoro, Antonino" uniqKey="D Assoro A" first="Antonino" last="D'Assoro">Antonino D'Assoro</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Drobot, Lyudmyla" sort="Drobot, Lyudmyla" uniqKey="Drobot L" first="Lyudmyla" last="Drobot">Lyudmyla Drobot</name><affiliation wicri:level="1"><nlm:affiliation>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv</wicri:regionArea><wicri:noRegion>Kyiv</wicri:noRegion></affiliation></author><author><name sortKey="Rakus, Dariusz" sort="Rakus, Dariusz" uniqKey="Rakus D" first="Dariusz" last="Rakus">Dariusz Rakus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Gizak, Agnieszka" sort="Gizak, Agnieszka" uniqKey="Gizak A" first="Agnieszka" last="Gizak">Agnieszka Gizak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Laidler, Piotr" sort="Laidler, Piotr" uniqKey="Laidler P" first="Piotr" last="Laidler">Piotr Laidler</name><affiliation wicri:level="1"><nlm:affiliation>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków</wicri:regionArea><wicri:noRegion>Kraków</wicri:noRegion></affiliation></author><author><name sortKey="Duli Ska Litewka, Joanna" sort="Duli Ska Litewka, Joanna" uniqKey="Duli Ska Litewka J" first="Joanna" last="Duli Ska-Litewka">Joanna Duli Ska-Litewka</name><affiliation wicri:level="1"><nlm:affiliation>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków</wicri:regionArea><wicri:noRegion>Kraków</wicri:noRegion></affiliation></author><author><name sortKey="Basecke, Joerg" sort="Basecke, Joerg" uniqKey="Basecke J" first="Joerg" last="Basecke">Joerg Basecke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine University of Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine University of Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Mijatovic, Sanja" sort="Mijatovic, Sanja" uniqKey="Mijatovic S" first="Sanja" last="Mijatovic">Sanja Mijatovic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Maksimovic Ivanic, Danijela" sort="Maksimovic Ivanic, Danijela" uniqKey="Maksimovic Ivanic D" first="Danijela" last="Maksimovic-Ivanic">Danijela Maksimovic-Ivanic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Montalto, Giuseppe" sort="Montalto, Giuseppe" uniqKey="Montalto G" first="Giuseppe" last="Montalto">Giuseppe Montalto</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy; Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy; Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Cervello, Melchiorre" sort="Cervello, Melchiorre" uniqKey="Cervello M" first="Melchiorre" last="Cervello">Melchiorre Cervello</name><affiliation wicri:level="1"><nlm:affiliation>Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Fitzgerald, Timothy L" sort="Fitzgerald, Timothy L" uniqKey="Fitzgerald T" first="Timothy L" last="Fitzgerald">Timothy L. Fitzgerald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Brody School of Medicine at East Carolina University, Greenville, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Surgery, Brody School of Medicine at East Carolina University, Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Demidenko, Zoya" sort="Demidenko, Zoya" uniqKey="Demidenko Z" first="Zoya" last="Demidenko">Zoya Demidenko</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Martelli, Alberto M" sort="Martelli, Alberto M" uniqKey="Martelli A" first="Alberto M" last="Martelli">Alberto M. Martelli</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Cocco, Lucio" sort="Cocco, Lucio" uniqKey="Cocco L" first="Lucio" last="Cocco">Lucio Cocco</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Steelman, Linda S" sort="Steelman, Linda S" uniqKey="Steelman L" first="Linda S" last="Steelman">Linda S. Steelman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Mccubrey, James A" sort="Mccubrey, James A" uniqKey="Mccubrey J" first="James A" last="Mccubrey">James A. Mccubrey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25051360</idno><idno type="pmid">25051360</idno><idno type="pmc">PMC4148087</idno><idno type="doi">10.18632/oncotarget.2209</idno><idno type="wicri:Area/Main/Corpus">000E10</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000E10</idno><idno type="wicri:Area/Main/Curation">000E10</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000E10</idno><idno type="wicri:Area/Main/Exploration">000E10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.</title><author><name sortKey="Davis, Nicole M" sort="Davis, Nicole M" uniqKey="Davis N" first="Nicole M" last="Davis">Nicole M. Davis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Sokolosky, Melissa" sort="Sokolosky, Melissa" uniqKey="Sokolosky M" first="Melissa" last="Sokolosky">Melissa Sokolosky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Stadelman, Kristin" sort="Stadelman, Kristin" uniqKey="Stadelman K" first="Kristin" last="Stadelman">Kristin Stadelman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Abrams, Steve L" sort="Abrams, Steve L" uniqKey="Abrams S" first="Steve L" last="Abrams">Steve L. Abrams</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Libra, Massimo" sort="Libra, Massimo" uniqKey="Libra M" first="Massimo" last="Libra">Massimo Libra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Bio-Medical Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Candido, Saverio" sort="Candido, Saverio" uniqKey="Candido S" first="Saverio" last="Candido">Saverio Candido</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Bio-Medical Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Nicoletti, Ferdinando" sort="Nicoletti, Ferdinando" uniqKey="Nicoletti F" first="Ferdinando" last="Nicoletti">Ferdinando Nicoletti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Bio-Medical Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Polesel, Jerry" sort="Polesel, Jerry" uniqKey="Polesel J" first="Jerry" last="Polesel">Jerry Polesel</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano</wicri:regionArea><wicri:noRegion>Aviano</wicri:noRegion></affiliation></author><author><name sortKey="Maestro, Roberta" sort="Maestro, Roberta" uniqKey="Maestro R" first="Roberta" last="Maestro">Roberta Maestro</name><affiliation wicri:level="1"><nlm:affiliation>Experimental Oncology 1, CRO IRCCS, National Cancer Institute, Aviano, Pordenone, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Experimental Oncology 1, CRO IRCCS, National Cancer Institute, Aviano, Pordenone</wicri:regionArea><wicri:noRegion>Pordenone</wicri:noRegion></affiliation></author><author><name sortKey="D Assoro, Antonino" sort="D Assoro, Antonino" uniqKey="D Assoro A" first="Antonino" last="D'Assoro">Antonino D'Assoro</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Drobot, Lyudmyla" sort="Drobot, Lyudmyla" uniqKey="Drobot L" first="Lyudmyla" last="Drobot">Lyudmyla Drobot</name><affiliation wicri:level="1"><nlm:affiliation>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv</wicri:regionArea><wicri:noRegion>Kyiv</wicri:noRegion></affiliation></author><author><name sortKey="Rakus, Dariusz" sort="Rakus, Dariusz" uniqKey="Rakus D" first="Dariusz" last="Rakus">Dariusz Rakus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Gizak, Agnieszka" sort="Gizak, Agnieszka" uniqKey="Gizak A" first="Agnieszka" last="Gizak">Agnieszka Gizak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Laidler, Piotr" sort="Laidler, Piotr" uniqKey="Laidler P" first="Piotr" last="Laidler">Piotr Laidler</name><affiliation wicri:level="1"><nlm:affiliation>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków</wicri:regionArea><wicri:noRegion>Kraków</wicri:noRegion></affiliation></author><author><name sortKey="Duli Ska Litewka, Joanna" sort="Duli Ska Litewka, Joanna" uniqKey="Duli Ska Litewka J" first="Joanna" last="Duli Ska-Litewka">Joanna Duli Ska-Litewka</name><affiliation wicri:level="1"><nlm:affiliation>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków</wicri:regionArea><wicri:noRegion>Kraków</wicri:noRegion></affiliation></author><author><name sortKey="Basecke, Joerg" sort="Basecke, Joerg" uniqKey="Basecke J" first="Joerg" last="Basecke">Joerg Basecke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine University of Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine University of Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Mijatovic, Sanja" sort="Mijatovic, Sanja" uniqKey="Mijatovic S" first="Sanja" last="Mijatovic">Sanja Mijatovic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Maksimovic Ivanic, Danijela" sort="Maksimovic Ivanic, Danijela" uniqKey="Maksimovic Ivanic D" first="Danijela" last="Maksimovic-Ivanic">Danijela Maksimovic-Ivanic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Montalto, Giuseppe" sort="Montalto, Giuseppe" uniqKey="Montalto G" first="Giuseppe" last="Montalto">Giuseppe Montalto</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy; Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy; Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Cervello, Melchiorre" sort="Cervello, Melchiorre" uniqKey="Cervello M" first="Melchiorre" last="Cervello">Melchiorre Cervello</name><affiliation wicri:level="1"><nlm:affiliation>Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Fitzgerald, Timothy L" sort="Fitzgerald, Timothy L" uniqKey="Fitzgerald T" first="Timothy L" last="Fitzgerald">Timothy L. Fitzgerald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Brody School of Medicine at East Carolina University, Greenville, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Surgery, Brody School of Medicine at East Carolina University, Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Demidenko, Zoya" sort="Demidenko, Zoya" uniqKey="Demidenko Z" first="Zoya" last="Demidenko">Zoya Demidenko</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Martelli, Alberto M" sort="Martelli, Alberto M" uniqKey="Martelli A" first="Alberto M" last="Martelli">Alberto M. Martelli</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Cocco, Lucio" sort="Cocco, Lucio" uniqKey="Cocco L" first="Lucio" last="Cocco">Lucio Cocco</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Steelman, Linda S" sort="Steelman, Linda S" uniqKey="Steelman L" first="Linda S" last="Steelman">Linda S. Steelman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author><author><name sortKey="Mccubrey, James A" sort="Mccubrey, James A" uniqKey="Mccubrey J" first="James A" last="Mccubrey">James A. Mccubrey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville</wicri:cityArea></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (genetics)</term><term>Class I Phosphatidylinositol 3-Kinases (MeSH)</term><term>ErbB Receptors (genetics)</term><term>Female (MeSH)</term><term>Gene Expression Regulation, Neoplastic (MeSH)</term><term>Humans (MeSH)</term><term>Mechanistic Target of Rapamycin Complex 1 (MeSH)</term><term>Multiprotein Complexes (genetics)</term><term>PTEN Phosphohydrolase (genetics)</term><term>Phosphatidylinositol 3-Kinases (genetics)</term><term>Proto-Oncogene Proteins c-akt (genetics)</term><term>Signal Transduction (genetics)</term><term>TOR Serine-Threonine Kinases (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term><term>Complexes multiprotéiques (génétique)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Phosphatidylinositol 3-kinases (génétique)</term><term>Phosphatidylinositol 3-kinases de classe I (MeSH)</term><term>Phosphohydrolase PTEN (génétique)</term><term>Protéines proto-oncogènes c-akt (génétique)</term><term>Récepteurs ErbB (génétique)</term><term>Régulation de l'expression des gènes tumoraux (MeSH)</term><term>Sérine-thréonine kinases TOR (génétique)</term><term>Transduction du signal (génétique)</term><term>Tumeurs du sein (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>ErbB Receptors</term><term>Multiprotein Complexes</term><term>PTEN Phosphohydrolase</term><term>Phosphatidylinositol 3-Kinases</term><term>Proto-Oncogene Proteins c-akt</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Class I Phosphatidylinositol 3-Kinases</term><term>Mechanistic Target of Rapamycin Complex 1</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexes multiprotéiques</term><term>Phosphatidylinositol 3-kinases</term><term>Phosphohydrolase PTEN</term><term>Protéines proto-oncogènes c-akt</term><term>Récepteurs ErbB</term><term>Sérine-thréonine kinases TOR</term><term>Transduction du signal</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Gene Expression Regulation, Neoplastic</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term><term>Femelle</term><term>Humains</term><term>Phosphatidylinositol 3-kinases de classe I</term><term>Régulation de l'expression des gènes tumoraux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstream HER2 has been associated with breast cancer initiating cells (CICs) and in some cases resistance to treatment. The anti-diabetes drug metformin can suppress the growth of breast CICs and herceptin-resistant HER2+ cells. This review will discuss the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway primarily in breast cancer but will also include relevant examples from other cancer types. The targeting of this pathway will be discussed as well as clinical trials with novel small molecule inhibitors. The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be reviewed in association with suppression of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25051360</PMID><DateCompleted><Year>2015</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>13</Issue><PubDate><Year>2014</Year><Month>Jul</Month><Day>15</Day></PubDate></JournalIssue><Title>Oncotarget</Title><ISOAbbreviation>Oncotarget</ISOAbbreviation></Journal><ArticleTitle>Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.</ArticleTitle><Pagination><MedlinePgn>4603-50</MedlinePgn></Pagination><Abstract><AbstractText>The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstream HER2 has been associated with breast cancer initiating cells (CICs) and in some cases resistance to treatment. The anti-diabetes drug metformin can suppress the growth of breast CICs and herceptin-resistant HER2+ cells. This review will discuss the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway primarily in breast cancer but will also include relevant examples from other cancer types. The targeting of this pathway will be discussed as well as clinical trials with novel small molecule inhibitors. The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be reviewed in association with suppression of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>Nicole M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sokolosky</LastName><ForeName>Melissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stadelman</LastName><ForeName>Kristin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abrams</LastName><ForeName>Steve L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Libra</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Candido</LastName><ForeName>Saverio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicoletti</LastName><ForeName>Ferdinando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Bio-Medical Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polesel</LastName><ForeName>Jerry</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maestro</LastName><ForeName>Roberta</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Experimental Oncology 1, CRO IRCCS, National Cancer Institute, Aviano, Pordenone, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Assoro</LastName><ForeName>Antonino</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drobot</LastName><ForeName>Lyudmyla</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rakus</LastName><ForeName>Dariusz</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gizak</LastName><ForeName>Agnieszka</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laidler</LastName><ForeName>Piotr</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dulińska-Litewka</LastName><ForeName>Joanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Basecke</LastName><ForeName>Joerg</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine University of Göttingen, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mijatovic</LastName><ForeName>Sanja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maksimovic-Ivanic</LastName><ForeName>Danijela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Immunology, Institute for Biological Research "Sinisa Stankovic" University of Belgrade, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montalto</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy; Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cervello</LastName><ForeName>Melchiorre</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fitzgerald</LastName><ForeName>Timothy L</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Department of Surgery, Brody School of Medicine at East Carolina University, Greenville, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demidenko</LastName><ForeName>Zoya</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martelli</LastName><ForeName>Alberto M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cocco</LastName><ForeName>Lucio</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steelman</LastName><ForeName>Linda S</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCubrey</LastName><ForeName>James A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Oncotarget</MedlineTA><NlmUniqueID>101532965</NlmUniqueID><ISSNLinking>1949-2553</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="D019869">Phosphatidylinositol 3-Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.137</RegistryNumber><NameOfSubstance UI="D058534">Class I Phosphatidylinositol 3-Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.137</RegistryNumber><NameOfSubstance UI="C484760">PIK3CA protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D066246">ErbB Receptors</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.3.67</RegistryNumber><NameOfSubstance UI="D051059">PTEN Phosphohydrolase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.3.67</RegistryNumber><NameOfSubstance UI="C494929">PTEN protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058534" MajorTopicYN="N">Class I Phosphatidylinositol 3-Kinases</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066246" MajorTopicYN="N">ErbB Receptors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046912" MajorTopicYN="N">Multiprotein Complexes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051059" MajorTopicYN="N">PTEN Phosphohydrolase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019869" MajorTopicYN="N">Phosphatidylinositol 3-Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25051360</ArticleId><ArticleId IdType="pii">2209</ArticleId><ArticleId IdType="pmc">PMC4148087</ArticleId><ArticleId IdType="doi">10.18632/oncotarget.2209</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Mol Cancer. 2008;7:83</Citation><ArticleIdList><ArticleId IdType="pubmed">18990230</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Mar;3(3):299-313</Citation><ArticleIdList><ArticleId IdType="pubmed">22431556</ArticleId></ArticleIdList></Reference><Reference><Citation>J Recept Signal Transduct Res. 2012 Dec;32(6):290-7</Citation><ArticleIdList><ArticleId IdType="pubmed">23194197</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2013 Sep 15;19(18):4911-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23801166</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Dec 1;10(23):4149-61</Citation><ArticleIdList><ArticleId IdType="pubmed">22101269</ArticleId></ArticleIdList></Reference><Reference><Citation>J Natl Cancer Inst. 2014 Jan;106(1):djt338</Citation><ArticleIdList><ArticleId IdType="pubmed">24317180</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2006 Aug;209(4):445-53</Citation><ArticleIdList><ArticleId IdType="pubmed">16739104</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2009 Aug 27;28(34):3022-32</Citation><ArticleIdList><ArticleId IdType="pubmed">19543317</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2011 Apr 15;71(8):2988-99</Citation><ArticleIdList><ArticleId IdType="pubmed">21363912</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Surg Investig. 2001;2(5):393-400</Citation><ArticleIdList><ArticleId IdType="pubmed">12678544</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2007 Aug 15;67(16):7756-64</Citation><ArticleIdList><ArticleId IdType="pubmed">17699780</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2003 Jul;200(3):290-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12845624</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2004 Nov 1;64(21):7678-81</Citation><ArticleIdList><ArticleId IdType="pubmed">15520168</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Treat Rev. 2014 Mar;40(2):259-70</Citation><ArticleIdList><ArticleId IdType="pubmed">24080156</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2013 Mar 1;73(5):1635-46</Citation><ArticleIdList><ArticleId IdType="pubmed">23442322</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Sep;3(9):954-87</Citation><ArticleIdList><ArticleId IdType="pubmed">23006971</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Health Geogr. 2011;10:32</Citation><ArticleIdList><ArticleId IdType="pubmed">21569288</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Jul;2(7):562-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21725138</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2007 Jul 15;110(2):735-42</Citation><ArticleIdList><ArticleId IdType="pubmed">17463171</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2013;3:2474</Citation><ArticleIdList><ArticleId IdType="pubmed">23959174</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Cell Res. 2011 Feb 15;317(4):392-404</Citation><ArticleIdList><ArticleId IdType="pubmed">21110957</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2003 Nov 1;9(14):5078-84</Citation><ArticleIdList><ArticleId IdType="pubmed">14613984</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2010 Jul;120(7):2406-13</Citation><ArticleIdList><ArticleId IdType="pubmed">20530877</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health. 2012;11:28</Citation><ArticleIdList><ArticleId IdType="pubmed">22534004</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2006 Sep 1;12(17):5074-81</Citation><ArticleIdList><ArticleId IdType="pubmed">16951223</ArticleId></ArticleIdList></Reference><Reference><Citation>BioDrugs. 2007;21(5):299-310</Citation><ArticleIdList><ArticleId IdType="pubmed">17896836</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2013 Jul 1;73(13):4075-85</Citation><ArticleIdList><ArticleId IdType="pubmed">23633485</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 1992 Oct 1;52(19):5291-8</Citation><ArticleIdList><ArticleId IdType="pubmed">1394133</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jul 15;11(14):2747-55</Citation><ArticleIdList><ArticleId IdType="pubmed">22751436</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Anticancer Ther. 2012 Feb;12(2):223-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22316370</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1783-91</Citation><ArticleIdList><ArticleId IdType="pubmed">23020162</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2010 Sep 16;29(37):5193-203</Citation><ArticleIdList><ArticleId IdType="pubmed">20581867</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Intern Med. 2012 Jul 9;172(13):1023-7</Citation><ArticleIdList><ArticleId IdType="pubmed">22688684</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Oncol. 2012 Feb;13(2):135-44</Citation><ArticleIdList><ArticleId IdType="pubmed">22257523</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Obstet Gynecol. 2011 Mar;54(1):96-102</Citation><ArticleIdList><ArticleId IdType="pubmed">21278508</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Dec 1;10(23):4047-64</Citation><ArticleIdList><ArticleId IdType="pubmed">22134189</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jun 15;11(12):2348-58</Citation><ArticleIdList><ArticleId IdType="pubmed">22672904</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Sep;3(9):988-97</Citation><ArticleIdList><ArticleId IdType="pubmed">22941871</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cancer. 2012 Jul 1;131(1):229-34</Citation><ArticleIdList><ArticleId IdType="pubmed">21834074</ArticleId></ArticleIdList></Reference><Reference><Citation>Mod Pathol. 2005 Aug;18(8):1027-33</Citation><ArticleIdList><ArticleId IdType="pubmed">15920544</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Oncol. 2001 Nov;12(11):1643-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11822766</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2008 Sep 15;7(18):2813-6</Citation><ArticleIdList><ArticleId IdType="pubmed">18769147</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 1999 Oct 15;59(20):5315-22</Citation><ArticleIdList><ArticleId IdType="pubmed">10537315</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2008 Apr 1;26(10):1596-602</Citation><ArticleIdList><ArticleId IdType="pubmed">18332467</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2010 May;121(1):53-64</Citation><ArticleIdList><ArticleId IdType="pubmed">19593635</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2012;14(1):R28</Citation><ArticleIdList><ArticleId IdType="pubmed">22330809</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Mar 1;10(5):794-804</Citation><ArticleIdList><ArticleId IdType="pubmed">21311224</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Anticancer Ther. 2010 Aug;10(8):1239-53</Citation><ArticleIdList><ArticleId IdType="pubmed">20735310</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell J. 2012 Summer;14(2):102-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23508069</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2002 Feb 1;20(3):719-26</Citation><ArticleIdList><ArticleId IdType="pubmed">11821453</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jan 15;11(2):367-76</Citation><ArticleIdList><ArticleId IdType="pubmed">22189713</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Nov 1;11(21):3983-96</Citation><ArticleIdList><ArticleId IdType="pubmed">22987153</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2006 Dec 1;66(23):11462-70</Citation><ArticleIdList><ArticleId IdType="pubmed">17145894</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Oncol. 2012 Jun;40(6):1858-64</Citation><ArticleIdList><ArticleId IdType="pubmed">22447278</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2012 Jul;134(2):531-41</Citation><ArticleIdList><ArticleId IdType="pubmed">22576469</ArticleId></ArticleIdList></Reference><Reference><Citation>Drugs. 2012 Feb 12;72(3):353-60</Citation><ArticleIdList><ArticleId IdType="pubmed">22316351</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2005 Jan 3;168(1):29-33</Citation><ArticleIdList><ArticleId IdType="pubmed">15631989</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2011;13(6):224</Citation><ArticleIdList><ArticleId IdType="pubmed">22114931</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Apr 1;11(7):1445-54</Citation><ArticleIdList><ArticleId IdType="pubmed">22395432</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2004;6(3):R246-51</Citation><ArticleIdList><ArticleId IdType="pubmed">15084248</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Endocrinol. 2011 Jan;25(1):72-82</Citation><ArticleIdList><ArticleId IdType="pubmed">21084382</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Oct;3(10):1236-45</Citation><ArticleIdList><ArticleId IdType="pubmed">23100449</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer. 2013 Feb 15;119(4):799-805</Citation><ArticleIdList><ArticleId IdType="pubmed">22972589</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2004 Sep;87(1):87-95</Citation><ArticleIdList><ArticleId IdType="pubmed">15377854</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2013 Oct 1;19(19):5390-401</Citation><ArticleIdList><ArticleId IdType="pubmed">23948973</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Jan 15;10(2):186</Citation><ArticleIdList><ArticleId IdType="pubmed">21239878</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2008 Mar 27;358(13):1409-11</Citation><ArticleIdList><ArticleId IdType="pubmed">18367751</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cancer. 2009 Nov 1;125(9):2021-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19588487</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Dec;3(12):1615-28</Citation><ArticleIdList><ArticleId IdType="pubmed">23271044</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Jun 15;10(12):2008-16</Citation><ArticleIdList><ArticleId IdType="pubmed">21558812</ArticleId></ArticleIdList></Reference><Reference><Citation>Minerva Chir. 2013 Apr;68(2):139-54</Citation><ArticleIdList><ArticleId IdType="pubmed">23612227</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2000 Jun 1;60(11):3081-7</Citation><ArticleIdList><ArticleId IdType="pubmed">10850460</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2011 Oct 6;30(40):4163-74</Citation><ArticleIdList><ArticleId IdType="pubmed">21499296</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2013 Jun 10;31(17):2073-5</Citation><ArticleIdList><ArticleId IdType="pubmed">23650407</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2008 Mar 1;68(5):1354-61</Citation><ArticleIdList><ArticleId IdType="pubmed">18316598</ArticleId></ArticleIdList></Reference><Reference><Citation>Hastings Cent Rep. 2006 May-Jun;36(3):13-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16776017</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cancer. 2010 Apr 15;126(8):1850-60</Citation><ArticleIdList><ArticleId IdType="pubmed">19830694</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Feb;3(2):212-23</Citation><ArticleIdList><ArticleId IdType="pubmed">22371431</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jul 1;11(13):2545-56</Citation><ArticleIdList><ArticleId IdType="pubmed">22722266</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Med Rep. 2008 Mar-Apr;1(2):139-60</Citation><ArticleIdList><ArticleId IdType="pubmed">21479390</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2007 Jun 8;282(23):16989-7001</Citation><ArticleIdList><ArticleId IdType="pubmed">17438332</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2014;13(5):820-33</Citation><ArticleIdList><ArticleId IdType="pubmed">24407515</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 May 15;10(10):1679-89</Citation><ArticleIdList><ArticleId IdType="pubmed">21508668</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2013 May 1;73(9):2840-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23447579</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Jul 15;10(14):2344-54</Citation><ArticleIdList><ArticleId IdType="pubmed">21654191</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Oct 1;11(19):3701-2</Citation><ArticleIdList><ArticleId IdType="pubmed">22895010</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Dec;3(12):1505-21</Citation><ArticleIdList><ArticleId IdType="pubmed">23455493</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Jun;3(6):601-7</Citation><ArticleIdList><ArticleId IdType="pubmed">22802145</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Dec;2(12):1155-64</Citation><ArticleIdList><ArticleId IdType="pubmed">22201704</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Dec 15;11(24):4579-88</Citation><ArticleIdList><ArticleId IdType="pubmed">23187804</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2010 Dec 2;363(23):2200-10</Citation><ArticleIdList><ArticleId IdType="pubmed">21121833</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2011;13(2):R35</Citation><ArticleIdList><ArticleId IdType="pubmed">21457545</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2010;12(3):R40</Citation><ArticleIdList><ArticleId IdType="pubmed">20569503</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2013 Jan;53(1):2-7</Citation><ArticleIdList><ArticleId IdType="pubmed">23058275</ArticleId></ArticleIdList></Reference><Reference><Citation>Maturitas. 2013 Dec;76(4):308-14</Citation><ArticleIdList><ArticleId IdType="pubmed">24128673</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2007 Nov 1;67(21):10286-95</Citation><ArticleIdList><ArticleId IdType="pubmed">17974970</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Lett. 2012 Oct 1;323(1):77-87</Citation><ArticleIdList><ArticleId IdType="pubmed">22484466</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 1993 Feb;8(2):279-88</Citation><ArticleIdList><ArticleId IdType="pubmed">8426737</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2001 Mar 1;61(5):2169-76</Citation><ArticleIdList><ArticleId IdType="pubmed">11280782</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Dec;3(12):1600-14</Citation><ArticleIdList><ArticleId IdType="pubmed">23307622</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Aug 1;11(15):2931-46</Citation><ArticleIdList><ArticleId IdType="pubmed">22833046</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Mar 15;10(6):956-62</Citation><ArticleIdList><ArticleId IdType="pubmed">21358261</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2013 Jun 15;12(12):1815-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23708511</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2010 Aug 1;28(22):3570-6</Citation><ArticleIdList><ArticleId IdType="pubmed">20606085</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Oncol. 2013 Sep 23;3:250</Citation><ArticleIdList><ArticleId IdType="pubmed">24069582</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jul 15;11(14):2699-710</Citation><ArticleIdList><ArticleId IdType="pubmed">22751440</ArticleId></ArticleIdList></Reference><Reference><Citation>Virchows Arch. 2010 Mar;456(3):235-43</Citation><ArticleIdList><ArticleId IdType="pubmed">20130907</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 1999 Jan;21(1):99-102</Citation><ArticleIdList><ArticleId IdType="pubmed">9916799</ArticleId></ArticleIdList></Reference><Reference><Citation>Drugs. 2013 Sep;73(13):1491-502</Citation><ArticleIdList><ArticleId IdType="pubmed">23982598</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Jan 15;10(2):187</Citation><ArticleIdList><ArticleId IdType="pubmed">21239879</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2012 Feb;120(2):a60-1</Citation><ArticleIdList><ArticleId IdType="pubmed">22297389</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Mar;2(3):251-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21436469</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Nov 1;11(21):3964-71</Citation><ArticleIdList><ArticleId IdType="pubmed">23082722</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2009 May 15;69(10):4116-24</Citation><ArticleIdList><ArticleId IdType="pubmed">19435916</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2013 Jul 1;73(13):3817-20</Citation><ArticleIdList><ArticleId IdType="pubmed">23794708</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Aug 1;11(15):2780-1</Citation><ArticleIdList><ArticleId IdType="pubmed">22833047</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2002;4(3):R4</Citation><ArticleIdList><ArticleId IdType="pubmed">12052256</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Cancer. 2014;14:170</Citation><ArticleIdList><ArticleId IdType="pubmed">24612502</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cell Biol. 2013;2013:973584</Citation><ArticleIdList><ArticleId IdType="pubmed">23935627</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2008 May 1;14(9):2673-80</Citation><ArticleIdList><ArticleId IdType="pubmed">18451231</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Cancer. 2004 Oct 18;91(8):1532-42</Citation><ArticleIdList><ArticleId IdType="pubmed">15480434</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Cancer. 2010;10:90</Citation><ArticleIdList><ArticleId IdType="pubmed">20219108</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2014 Jan 30;33(5):599-610</Citation><ArticleIdList><ArticleId IdType="pubmed">23334326</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 2013 Nov 1;86(9):1272-84</Citation><ArticleIdList><ArticleId IdType="pubmed">23973528</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2005 Mar 1;65(5):1961-72</Citation><ArticleIdList><ArticleId IdType="pubmed">15753396</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2013 Feb;138(1):21-35</Citation><ArticleIdList><ArticleId IdType="pubmed">23358903</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Feb 1;10(3):377</Citation><ArticleIdList><ArticleId IdType="pubmed">21270524</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cancer. 2002 Mar 20;98(3):357-61</Citation><ArticleIdList><ArticleId IdType="pubmed">11920586</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):247-58</Citation><ArticleIdList><ArticleId IdType="pubmed">18473151</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009;4(3):e4797</Citation><ArticleIdList><ArticleId IdType="pubmed">19274078</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Cell. 2009 Jul 7;16(1):21-32</Citation><ArticleIdList><ArticleId IdType="pubmed">19573809</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2012 Nov;136(1):267-75</Citation><ArticleIdList><ArticleId IdType="pubmed">23053646</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharmacol. 2013 Oct 5;717(1-3):47-57</Citation><ArticleIdList><ArticleId IdType="pubmed">23545365</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Cancer. 2011 Aug;2(8):792-804</Citation><ArticleIdList><ArticleId IdType="pubmed">22393464</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Dec;2(12):1218-26</Citation><ArticleIdList><ArticleId IdType="pubmed">22203467</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2007 Jan 18;26(3):462-6</Citation><ArticleIdList><ArticleId IdType="pubmed">16832345</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Mar 15;11(6):1108-17</Citation><ArticleIdList><ArticleId IdType="pubmed">22313602</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 May;3(5):514-5</Citation><ArticleIdList><ArticleId IdType="pubmed">22626783</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Med Chem. 2013;20(1):144-57</Citation><ArticleIdList><ArticleId IdType="pubmed">23033951</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Nov 15;10(22):3871-85</Citation><ArticleIdList><ArticleId IdType="pubmed">22127234</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Oncol. 2005 Nov;27(5):1341-4</Citation><ArticleIdList><ArticleId IdType="pubmed">16211230</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2008 Oct 16;27(47):6120-30</Citation><ArticleIdList><ArticleId IdType="pubmed">18591932</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2009 May 15;69(10):4192-201</Citation><ArticleIdList><ArticleId IdType="pubmed">19435893</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Oncol. 2012 Sep;29(3):1569-75</Citation><ArticleIdList><ArticleId IdType="pubmed">22105146</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2012 May 15;72(10):2657-71</Citation><ArticleIdList><ArticleId IdType="pubmed">22419663</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Nov 15;11(22):4167-73</Citation><ArticleIdList><ArticleId IdType="pubmed">23047605</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Sep 1;10(17):3003-15</Citation><ArticleIdList><ArticleId IdType="pubmed">21869603</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pharmacol Exp Ther. 2010 Aug;334(2):467-76</Citation><ArticleIdList><ArticleId IdType="pubmed">20460386</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2009 Apr 1;15(7):2472-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19276248</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1990 Nov 30;250(4985):1233-8</Citation><ArticleIdList><ArticleId IdType="pubmed">1978757</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cancer Res. 2007 Feb;5(2):195-201</Citation><ArticleIdList><ArticleId IdType="pubmed">17314276</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Pathol. 2012 May;65(5):419-23</Citation><ArticleIdList><ArticleId IdType="pubmed">22412049</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2004 Jul 1;64(13):4585-92</Citation><ArticleIdList><ArticleId IdType="pubmed">15231670</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Aug 1;11(15):2782-92</Citation><ArticleIdList><ArticleId IdType="pubmed">22809961</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Pharm Des. 2012;18(13):1784-95</Citation><ArticleIdList><ArticleId IdType="pubmed">22394167</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2001 Sep;7(9):2898-907</Citation><ArticleIdList><ArticleId IdType="pubmed">11555608</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Feb 1;10(3):507-17</Citation><ArticleIdList><ArticleId IdType="pubmed">21270527</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncologist. 2014 Jun;19(6):608-15</Citation><ArticleIdList><ArticleId IdType="pubmed">24794159</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Dec;3(12):1629-40</Citation><ArticleIdList><ArticleId IdType="pubmed">23283305</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2005;7(6):R1028-35</Citation><ArticleIdList><ArticleId IdType="pubmed">16280056</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2005 Mar 1;65(5):1642-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15753357</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2008 Aug 1;68(15):6084-91</Citation><ArticleIdList><ArticleId IdType="pubmed">18676830</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):259-68</Citation><ArticleIdList><ArticleId IdType="pubmed">18454307</ArticleId></ArticleIdList></Reference><Reference><Citation>Virchows Arch. 2001 Jul;439(1):62-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11499842</ArticleId></ArticleIdList></Reference><Reference><Citation>CA Cancer J Clin. 2013 Mar-Apr;63(2):120-42</Citation><ArticleIdList><ArticleId IdType="pubmed">23322675</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2011;13(4):214</Citation><ArticleIdList><ArticleId IdType="pubmed">21867572</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncol Rep. 2013 May;29(5):1785-8</Citation><ArticleIdList><ArticleId IdType="pubmed">23446853</ArticleId></ArticleIdList></Reference><Reference><Citation>Anticancer Res. 2003 Mar-Apr;23(2B):1455-60</Citation><ArticleIdList><ArticleId IdType="pubmed">12820409</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Dec 1;11(23):4402-13</Citation><ArticleIdList><ArticleId IdType="pubmed">23172369</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2012 Nov 1;18(21):5856-64</Citation><ArticleIdList><ArticleId IdType="pubmed">23082003</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Sci. 2012 Mar;103(3):400-7</Citation><ArticleIdList><ArticleId IdType="pubmed">22151725</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2001 Nov;195(4):422-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11745673</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Sep 1;11(17):3159-65</Citation><ArticleIdList><ArticleId IdType="pubmed">22895181</ArticleId></ArticleIdList></Reference><Reference><Citation>Genetics. 2012 Oct;192(2):385-96</Citation><ArticleIdList><ArticleId IdType="pubmed">22851646</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2011 Jul;128(2):315-26</Citation><ArticleIdList><ArticleId IdType="pubmed">20697807</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncol Rep. 2013 Sep;30(3):1019-29</Citation><ArticleIdList><ArticleId IdType="pubmed">23779253</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1994 Oct 7;266(5182):66-71</Citation><ArticleIdList><ArticleId IdType="pubmed">7545954</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Aug;3(8):811-23</Citation><ArticleIdList><ArticleId IdType="pubmed">22885370</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncol Res. 2006;16(4):179-93</Citation><ArticleIdList><ArticleId IdType="pubmed">17120616</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2013 Feb 1;19(3):511-3</Citation><ArticleIdList><ArticleId IdType="pubmed">23251003</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hum Genet. 1997 Jul;61(1):120-8</Citation><ArticleIdList><ArticleId IdType="pubmed">9245992</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2011 Aug;119(8):1053-61</Citation><ArticleIdList><ArticleId IdType="pubmed">21697028</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncology (Williston Park). 2013 Jan;27(1):38-44, 46, 48 passim</Citation><ArticleIdList><ArticleId IdType="pubmed">23461041</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Cancer. 2009;9:325</Citation><ArticleIdList><ArticleId IdType="pubmed">19751508</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Discov. 2013 Feb;3(2):224-37</Citation><ArticleIdList><ArticleId IdType="pubmed">23220880</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Discov. 2011 Jul;1(2):170-85</Citation><ArticleIdList><ArticleId IdType="pubmed">21984976</ArticleId></ArticleIdList></Reference><Reference><Citation>Aging (Albany NY). 2012 Jul;4(7):480-98</Citation><ArticleIdList><ArticleId IdType="pubmed">22837425</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Feb 15;11(4):639-40</Citation><ArticleIdList><ArticleId IdType="pubmed">22374663</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1847-8</Citation><ArticleIdList><ArticleId IdType="pubmed">23134386</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Nov 1;11(21):4020-32</Citation><ArticleIdList><ArticleId IdType="pubmed">22992620</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Jan 12;366(2):109-19</Citation><ArticleIdList><ArticleId IdType="pubmed">22149875</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Dec 1;11(23):4447-61</Citation><ArticleIdList><ArticleId IdType="pubmed">23159854</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Nov 1;11(21):3956-63</Citation><ArticleIdList><ArticleId IdType="pubmed">23082721</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10208-13</Citation><ArticleIdList><ArticleId IdType="pubmed">20479250</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2012 Jul;18(7):1052-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22683778</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2011;6(10):e26760</Citation><ArticleIdList><ArticleId IdType="pubmed">22046346</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2010;5(12):e15647</Citation><ArticleIdList><ArticleId IdType="pubmed">21209903</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Mar 1;11(5):1008-13</Citation><ArticleIdList><ArticleId IdType="pubmed">22333593</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 1992 Feb;10(2):304-10</Citation><ArticleIdList><ArticleId IdType="pubmed">1732430</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Jun;2(6):435-47</Citation><ArticleIdList><ArticleId IdType="pubmed">21646685</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2009 Aug;119(8):2171-83</Citation><ArticleIdList><ArticleId IdType="pubmed">19620787</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2014 May 15;20(10):2508-15</Citation><ArticleIdList><ArticleId IdType="pubmed">24682417</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Jan;3(1):5-6</Citation><ArticleIdList><ArticleId IdType="pubmed">22403740</ArticleId></ArticleIdList></Reference><Reference><Citation>J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2012;30(3):189-224</Citation><ArticleIdList><ArticleId IdType="pubmed">22970719</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Biol Ther. 2008 Nov;7(11):1818-28</Citation><ArticleIdList><ArticleId IdType="pubmed">18787418</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2011 Apr;126(2):355-64</Citation><ArticleIdList><ArticleId IdType="pubmed">20458531</ArticleId></ArticleIdList></Reference><Reference><Citation>Tumour Biol. 2013 Dec;34(6):3945-58</Citation><ArticleIdList><ArticleId IdType="pubmed">23860775</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2013 Jan;53(1):146-55</Citation><ArticleIdList><ArticleId IdType="pubmed">23073564</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 May 1;10(9):1411-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21451261</ArticleId></ArticleIdList></Reference><Reference><Citation>Leukemia. 2012 Nov;26(11):2336-42</Citation><ArticleIdList><ArticleId IdType="pubmed">22614243</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Cancer. 1998 Nov;78(10):1385-90</Citation><ArticleIdList><ArticleId IdType="pubmed">9823984</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2001 Mar 1;410(6824):50-6</Citation><ArticleIdList><ArticleId IdType="pubmed">11242036</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2009 Jan 10;27(2):227-34</Citation><ArticleIdList><ArticleId IdType="pubmed">19064988</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncol Rep. 2008 May;19(5):1149-53</Citation><ArticleIdList><ArticleId IdType="pubmed">18425370</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2013 Jun 15;73(12):3489-93</Citation><ArticleIdList><ArticleId IdType="pubmed">23740771</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Cell Res. 2003 Mar 10;284(1):66-77</Citation><ArticleIdList><ArticleId IdType="pubmed">12648466</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2011 Jan;125(2):447-55</Citation><ArticleIdList><ArticleId IdType="pubmed">21107682</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2012;14(5):R138</Citation><ArticleIdList><ArticleId IdType="pubmed">23102376</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2002 Jan;196(1):17-25</Citation><ArticleIdList><ArticleId IdType="pubmed">11748637</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 May 15;10(10):1563-70</Citation><ArticleIdList><ArticleId IdType="pubmed">21502814</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2013 Jan 15;12(2):225-45</Citation><ArticleIdList><ArticleId IdType="pubmed">23255137</ArticleId></ArticleIdList></Reference><Reference><Citation>Aging (Albany NY). 2011 May;3(5):515-32</Citation><ArticleIdList><ArticleId IdType="pubmed">21666281</ArticleId></ArticleIdList></Reference><Reference><Citation>CA Cancer J Clin. 2013 Jan;63(1):11-30</Citation><ArticleIdList><ArticleId IdType="pubmed">23335087</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Sep;3(9):998-1010</Citation><ArticleIdList><ArticleId IdType="pubmed">22948175</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Lett. 2011 Jul 1;306(1):43-51</Citation><ArticleIdList><ArticleId IdType="pubmed">21454012</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2010 Jul;122(1):11-25</Citation><ArticleIdList><ArticleId IdType="pubmed">20376556</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2003 Mar;9(3):1161-70</Citation><ArticleIdList><ArticleId IdType="pubmed">12631622</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Mol Diagn. 2008 Jul;8(4):417-34</Citation><ArticleIdList><ArticleId IdType="pubmed">18598224</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Oncol. 2012 Jun;29(2):472-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21365326</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Jul;3(7):666-7</Citation><ArticleIdList><ArticleId IdType="pubmed">22837432</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Aug;3(8):833-42</Citation><ArticleIdList><ArticleId IdType="pubmed">22909995</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Pharmacol Toxicol. 2012;52:455-79</Citation><ArticleIdList><ArticleId IdType="pubmed">22017681</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Cell Biol. 2003 Jun;15(3):345-50</Citation><ArticleIdList><ArticleId IdType="pubmed">12787778</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2013 Oct 15;19(20):5552-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23942091</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2014 Jan;54:176-96</Citation><ArticleIdList><ArticleId IdType="pubmed">24169510</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Cell. 2013 Aug 12;24(2):197-212</Citation><ArticleIdList><ArticleId IdType="pubmed">23948299</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jul 1;11(13):2452-7</Citation><ArticleIdList><ArticleId IdType="pubmed">22659842</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Enzyme Regul. 2008;48:113-35</Citation><ArticleIdList><ArticleId IdType="pubmed">18423407</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Oct 15;11(20):3837-50</Citation><ArticleIdList><ArticleId IdType="pubmed">22983061</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jan 1;11(1):17</Citation><ArticleIdList><ArticleId IdType="pubmed">22186784</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2014 Jan;54:2-11</Citation><ArticleIdList><ArticleId IdType="pubmed">24296032</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2013 Oct 1;19(19):5264-74</Citation><ArticleIdList><ArticleId IdType="pubmed">24089439</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Cancer. 2013 May 14;108(9):1807-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23612454</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Oncol. 2013 Nov;25(6):587-93</Citation><ArticleIdList><ArticleId IdType="pubmed">24097108</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2013 Jan 10;31(2):195-202</Citation><ArticleIdList><ArticleId IdType="pubmed">23233719</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2011 Oct 1;29(28):3739-46</Citation><ArticleIdList><ArticleId IdType="pubmed">21900106</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Sep 1;10(17):2959-66</Citation><ArticleIdList><ArticleId IdType="pubmed">21862872</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Oct;3(10):1068-111</Citation><ArticleIdList><ArticleId IdType="pubmed">23085539</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2014;9(5):e96995</Citation><ArticleIdList><ArticleId IdType="pubmed">24816249</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Environ Health Res. 2012;22(1):12-21</Citation><ArticleIdList><ArticleId IdType="pubmed">21644128</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16158-63</Citation><ArticleIdList><ArticleId IdType="pubmed">17911267</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Jan 26;366(4):299-309</Citation><ArticleIdList><ArticleId IdType="pubmed">22276820</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2008 Jul 3;27(29):4086-95</Citation><ArticleIdList><ArticleId IdType="pubmed">18332865</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2011;6(4):e19249</Citation><ArticleIdList><ArticleId IdType="pubmed">21556366</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Cancer. 2012;12:510</Citation><ArticleIdList><ArticleId IdType="pubmed">23146383</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Cancer. 2007 Aug 20;97(4):453-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17667926</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2011 Mar 1;17(5):1082-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21233401</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Apr;3(4):395-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22565037</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Sci. 2004 Nov;95(11):866-71</Citation><ArticleIdList><ArticleId IdType="pubmed">15546503</ArticleId></ArticleIdList></Reference><Reference><Citation>J Natl Cancer Inst. 1995 Nov 1;87(21):1642</Citation><ArticleIdList><ArticleId IdType="pubmed">7563210</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8933-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12853564</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Med Genomics. 2010;3:26</Citation><ArticleIdList><ArticleId IdType="pubmed">20591134</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer. 2011 Jul 15;117(14):3093-100</Citation><ArticleIdList><ArticleId IdType="pubmed">21264845</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Cancer. 2006 Oct;42(15):2617-22</Citation><ArticleIdList><ArticleId IdType="pubmed">16956761</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1531-43</Citation><ArticleIdList><ArticleId IdType="pubmed">12496040</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Cancer Res. 2013;3(1):46-57</Citation><ArticleIdList><ArticleId IdType="pubmed">23359227</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2011 Aug 10;29(23):3126-32</Citation><ArticleIdList><ArticleId IdType="pubmed">21730275</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cancer. 2012 Aug 15;131(4):930-7</Citation><ArticleIdList><ArticleId IdType="pubmed">21952983</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Environ Res Public Health. 2012 May;9(5):1846-58</Citation><ArticleIdList><ArticleId IdType="pubmed">22754477</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncologist. 2011;16(3):276-85</Citation><ArticleIdList><ArticleId IdType="pubmed">21339261</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Apr;3(4):371-94</Citation><ArticleIdList><ArticleId IdType="pubmed">22564882</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Med Rep. 2008 Jul-Aug;1(4):451-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21479431</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jun 1;11(11):2137-45</Citation><ArticleIdList><ArticleId IdType="pubmed">22592534</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2000 Apr 15;14(8):927-39</Citation><ArticleIdList><ArticleId IdType="pubmed">10783165</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Oct;2(10):797-809</Citation><ArticleIdList><ArticleId IdType="pubmed">22006582</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jul 15;11(14):2756-61</Citation><ArticleIdList><ArticleId IdType="pubmed">22767154</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jul 1;11(13):2443-51</Citation><ArticleIdList><ArticleId IdType="pubmed">22659843</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cancer Res Clin Oncol. 2010 Nov;136(11):1657-69</Citation><ArticleIdList><ArticleId IdType="pubmed">20177704</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Mar 1;11(5):865-70</Citation><ArticleIdList><ArticleId IdType="pubmed">22333588</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Dec 15;11(24):4597-612</Citation><ArticleIdList><ArticleId IdType="pubmed">23187807</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2013 Feb 1;73(3):1190-200</Citation><ArticleIdList><ArticleId IdType="pubmed">23204226</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Nov 1;11(21):4079-92</Citation><ArticleIdList><ArticleId IdType="pubmed">23095522</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Apr 1;10(7):1144-51</Citation><ArticleIdList><ArticleId IdType="pubmed">21368581</ArticleId></ArticleIdList></Reference><Reference><Citation>J Intern Med. 2013 Aug;274(2):144-52</Citation><ArticleIdList><ArticleId IdType="pubmed">23844917</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 1999 Mar 18;18(11):1957-65</Citation><ArticleIdList><ArticleId IdType="pubmed">10208417</ArticleId></ArticleIdList></Reference><Reference><Citation>Growth Factors. 2008 Oct;26(5):263-74</Citation><ArticleIdList><ArticleId IdType="pubmed">18800267</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Feb 15;11(4):687-94</Citation><ArticleIdList><ArticleId IdType="pubmed">22306997</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2007 Oct 1;25(28):4405-13</Citation><ArticleIdList><ArticleId IdType="pubmed">17906204</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Adv Hematol Oncol. 2011 May;9(5 Suppl 10):1-16</Citation><ArticleIdList><ArticleId IdType="pubmed">21738118</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Lett. 2012 Oct 1;323(1):97-105</Citation><ArticleIdList><ArticleId IdType="pubmed">22521545</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2009 Mar 15;15(6):1845-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19276254</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Opin Ther Targets. 2012 Jul;16(7):729-42</Citation><ArticleIdList><ArticleId IdType="pubmed">22686561</ArticleId></ArticleIdList></Reference><Reference><Citation>Future Oncol. 2006 Feb;2(1):91-100</Citation><ArticleIdList><ArticleId IdType="pubmed">16556076</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2014 Jan;143(2):325-32</Citation><ArticleIdList><ArticleId IdType="pubmed">24327334</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2012 Jan;52(1):249-64</Citation><ArticleIdList><ArticleId IdType="pubmed">21930143</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Mol Pathol. 2008 Apr;84(2):79-89</Citation><ArticleIdList><ArticleId IdType="pubmed">18279851</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2013 Apr;123(4):1821-32</Citation><ArticleIdList><ArticleId IdType="pubmed">23549082</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Manag Res. 2013 Aug 26;5:281-92</Citation><ArticleIdList><ArticleId IdType="pubmed">24009430</ArticleId></ArticleIdList></Reference><Reference><Citation>Gynecol Oncol. 2005 Nov;99(2):415-21</Citation><ArticleIdList><ArticleId IdType="pubmed">16157365</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):20-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15668471</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Aug;2(8):588-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21876228</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 May 15;10(10):1525</Citation><ArticleIdList><ArticleId IdType="pubmed">21502809</ArticleId></ArticleIdList></Reference><Reference><Citation>Aging (Albany NY). 2011 Apr;3(4):348-62</Citation><ArticleIdList><ArticleId IdType="pubmed">21483040</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Cell. 2007 Oct;12(4):395-402</Citation><ArticleIdList><ArticleId IdType="pubmed">17936563</ArticleId></ArticleIdList></Reference><Reference><Citation>Aging (Albany NY). 2011 May;3(5):461-3</Citation><ArticleIdList><ArticleId IdType="pubmed">21805697</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Oncol. 2013 Jan;14(1):72-80</Citation><ArticleIdList><ArticleId IdType="pubmed">23246022</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Dec 1;10(23):4119-27</Citation><ArticleIdList><ArticleId IdType="pubmed">22101277</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Lett. 2003 Mar 20;192(1):67-74</Citation><ArticleIdList><ArticleId IdType="pubmed">12637154</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2006 Jun 23;22(6):719-29</Citation><ArticleIdList><ArticleId IdType="pubmed">16793542</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Jul 1;11(13):2467-75</Citation><ArticleIdList><ArticleId IdType="pubmed">22713244</ArticleId></ArticleIdList></Reference><Reference><Citation>Toxicology. 2012 Jun 14;296(1-3):67-72</Citation><ArticleIdList><ArticleId IdType="pubmed">22465873</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Biosci (Landmark Ed). 2013;18:1358-72</Citation><ArticleIdList><ArticleId IdType="pubmed">23747889</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2000 Nov;6(11):4217-25</Citation><ArticleIdList><ArticleId IdType="pubmed">11106235</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Nov 15;11(22):4242-51</Citation><ArticleIdList><ArticleId IdType="pubmed">23095640</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Aug;3(8):869-81</Citation><ArticleIdList><ArticleId IdType="pubmed">22935625</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2010 Jul;122(1):45-53</Citation><ArticleIdList><ArticleId IdType="pubmed">19701705</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Sep;2(9):654-6</Citation><ArticleIdList><ArticleId IdType="pubmed">21926448</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 May;2(5):378-92</Citation><ArticleIdList><ArticleId IdType="pubmed">21623005</ArticleId></ArticleIdList></Reference><Reference><Citation>Diagn Mol Pathol. 2007 Dec;16(4):218-21</Citation><ArticleIdList><ArticleId IdType="pubmed">18043285</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Med Res Opin. 2014 Jan;30(1):75-87</Citation><ArticleIdList><ArticleId IdType="pubmed">24050600</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Feb 1;11(3):433-4</Citation><ArticleIdList><ArticleId IdType="pubmed">22293402</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013;8(1):e53403</Citation><ArticleIdList><ArticleId IdType="pubmed">23301067</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cancer Ther. 2011 Jun;10(6):1093-101</Citation><ArticleIdList><ArticleId IdType="pubmed">21490305</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2009 Sep;117(2):253-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18814026</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocr Relat Cancer. 2003 Mar;10(1):43-73</Citation><ArticleIdList><ArticleId IdType="pubmed">12653670</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2013 Jul 1;19(13):3533-44</Citation><ArticleIdList><ArticleId IdType="pubmed">23674493</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Oncol. 2007 Jan;18(1):203-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17220285</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 2010 Jun 20;28(18):2974-81</Citation><ArticleIdList><ArticleId IdType="pubmed">20479407</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Biol. 2009 Jun 2;7(6):e1000121</Citation><ArticleIdList><ArticleId IdType="pubmed">19492080</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Dec;3(12):1546-56</Citation><ArticleIdList><ArticleId IdType="pubmed">23295859</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013;8(3):e58182</Citation><ArticleIdList><ArticleId IdType="pubmed">23536787</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 1998 Sep 1;58(17):3932-41</Citation><ArticleIdList><ArticleId IdType="pubmed">9731505</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Cell. 2013 Sep 9;24(3):365-78</Citation><ArticleIdList><ArticleId IdType="pubmed">24029233</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2012 Jul;134(1):333-43</Citation><ArticleIdList><ArticleId IdType="pubmed">22538770</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2011 Jan 1;10(1):90-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21191178</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Jun;3(6):608-19</Citation><ArticleIdList><ArticleId IdType="pubmed">22689141</ArticleId></ArticleIdList></Reference><Reference><Citation>Leukemia. 2014 Apr;28(4):739-48</Citation><ArticleIdList><ArticleId IdType="pubmed">23892718</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Nov 15;11(22):4174-80</Citation><ArticleIdList><ArticleId IdType="pubmed">23070475</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncologist. 2013 Jun;18(6):661-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23697602</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Oct;2(10):810-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22021332</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Italie</li><li>Pologne</li><li>Serbie</li><li>Ukraine</li><li>États-Unis</li></country><region><li>Basse-Saxe</li><li>Caroline du Nord</li><li>Minnesota</li><li>Émilie-Romagne</li><li>État de New York</li></region><settlement><li>Bologne</li><li>Göttingen</li></settlement><orgName><li>Université de Bologne</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Davis, Nicole M" sort="Davis, Nicole M" uniqKey="Davis N" first="Nicole M" last="Davis">Nicole M. Davis</name></region><name sortKey="Abrams, Steve L" sort="Abrams, Steve L" uniqKey="Abrams S" first="Steve L" last="Abrams">Steve L. Abrams</name><name sortKey="D Assoro, Antonino" sort="D Assoro, Antonino" uniqKey="D Assoro A" first="Antonino" last="D'Assoro">Antonino D'Assoro</name><name sortKey="Demidenko, Zoya" sort="Demidenko, Zoya" uniqKey="Demidenko Z" first="Zoya" last="Demidenko">Zoya Demidenko</name><name sortKey="Fitzgerald, Timothy L" sort="Fitzgerald, Timothy L" uniqKey="Fitzgerald T" first="Timothy L" last="Fitzgerald">Timothy L. Fitzgerald</name><name sortKey="Mccubrey, James A" sort="Mccubrey, James A" uniqKey="Mccubrey J" first="James A" last="Mccubrey">James A. Mccubrey</name><name sortKey="Sokolosky, Melissa" sort="Sokolosky, Melissa" uniqKey="Sokolosky M" first="Melissa" last="Sokolosky">Melissa Sokolosky</name><name sortKey="Stadelman, Kristin" sort="Stadelman, Kristin" uniqKey="Stadelman K" first="Kristin" last="Stadelman">Kristin Stadelman</name><name sortKey="Steelman, Linda S" sort="Steelman, Linda S" uniqKey="Steelman L" first="Linda S" last="Steelman">Linda S. Steelman</name></country><country name="Italie"><noRegion><name sortKey="Libra, Massimo" sort="Libra, Massimo" uniqKey="Libra M" first="Massimo" last="Libra">Massimo Libra</name></noRegion><name sortKey="Candido, Saverio" sort="Candido, Saverio" uniqKey="Candido S" first="Saverio" last="Candido">Saverio Candido</name><name sortKey="Cervello, Melchiorre" sort="Cervello, Melchiorre" uniqKey="Cervello M" first="Melchiorre" last="Cervello">Melchiorre Cervello</name><name sortKey="Cocco, Lucio" sort="Cocco, Lucio" uniqKey="Cocco L" first="Lucio" last="Cocco">Lucio Cocco</name><name sortKey="Maestro, Roberta" sort="Maestro, Roberta" uniqKey="Maestro R" first="Roberta" last="Maestro">Roberta Maestro</name><name sortKey="Martelli, Alberto M" sort="Martelli, Alberto M" uniqKey="Martelli A" first="Alberto M" last="Martelli">Alberto M. Martelli</name><name sortKey="Montalto, Giuseppe" sort="Montalto, Giuseppe" uniqKey="Montalto G" first="Giuseppe" last="Montalto">Giuseppe Montalto</name><name sortKey="Nicoletti, Ferdinando" sort="Nicoletti, Ferdinando" uniqKey="Nicoletti F" first="Ferdinando" last="Nicoletti">Ferdinando Nicoletti</name><name sortKey="Polesel, Jerry" sort="Polesel, Jerry" uniqKey="Polesel J" first="Jerry" last="Polesel">Jerry Polesel</name></country><country name="Ukraine"><noRegion><name sortKey="Drobot, Lyudmyla" sort="Drobot, Lyudmyla" uniqKey="Drobot L" first="Lyudmyla" last="Drobot">Lyudmyla Drobot</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Rakus, Dariusz" sort="Rakus, Dariusz" uniqKey="Rakus D" first="Dariusz" last="Rakus">Dariusz Rakus</name></noRegion><name sortKey="Duli Ska Litewka, Joanna" sort="Duli Ska Litewka, Joanna" uniqKey="Duli Ska Litewka J" first="Joanna" last="Duli Ska-Litewka">Joanna Duli Ska-Litewka</name><name sortKey="Gizak, Agnieszka" sort="Gizak, Agnieszka" uniqKey="Gizak A" first="Agnieszka" last="Gizak">Agnieszka Gizak</name><name sortKey="Laidler, Piotr" sort="Laidler, Piotr" uniqKey="Laidler P" first="Piotr" last="Laidler">Piotr Laidler</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Basecke, Joerg" sort="Basecke, Joerg" uniqKey="Basecke J" first="Joerg" last="Basecke">Joerg Basecke</name></region></country><country name="Serbie"><noRegion><name sortKey="Mijatovic, Sanja" sort="Mijatovic, Sanja" uniqKey="Mijatovic S" first="Sanja" last="Mijatovic">Sanja Mijatovic</name></noRegion><name sortKey="Maksimovic Ivanic, Danijela" sort="Maksimovic Ivanic, Danijela" uniqKey="Maksimovic Ivanic D" first="Danijela" last="Maksimovic-Ivanic">Danijela Maksimovic-Ivanic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F00 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F00 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25051360
|texte= Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25051360" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |